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Home - Products - Proteasome/Ubiquitin - DUB - HBX 41108

HBX 41108

CAS No. 924296-39-9

HBX 41108 ( HBX-41108 )

Catalog No. M27424 CAS No. 924296-39-9

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HBX 41108
  • Note
    Research use only, not for human use.
  • Brief Description
    HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
  • Description
    HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
  • Synonyms
    HBX-41108
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    Bax;Bcl-2;Caspase-3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    924296-39-9
  • Formula Weight
    266.6
  • Molecular Formula
    C13H3ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhou D, et al. Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum. Phytochemistry. 2019;164:172-183.
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